A Washington State University researcher has demonstrated that a variety of environmental toxicants can have negative effects on not just an exposed animal but the next three generations of its offspring.The animal's DNA sequence remains unchanged, but the compounds change the way genes turn on and off -- the epigenetic effect studied at length by WSU molecular biologist Michael Skinner and expanded on in the current issue of the online journal PLoS ONE.
While Skinner's earlier research has shown similar effects from a pesticide and fungicide, this is the first to show a greater variety of toxicants -- including jet fuel, dioxin, plastics and the pesticides DEET and permethrin -- promoting epigenetic disease across generations.
"We didn't expect them all to have transgenerational effects, but all of them did," Skinner said. "I thought hydrocarbon would be negative but it was positive too."
This tells researchers that the ability to promote transgenerational disease is "not simply a unique aspect for a unique compound" but a characteristic of many environmental compounds. Read More
